Immunopathogenesis of Experimentally Induced Proliferative Enteropathy in Pigs

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Immunopathogenesis of experimentally induced proliferative enteropathy in pigs.

To characterize the immune response associated with Lawsonia intracellularis infection, twenty-eight, 7-week-old pigs were dosed orally with a pure culture of L. intracellularis. Animals were killed 3, 7, 14, 21, 28, 35, and 42 days postinfection. Light microscopic studies were undertaken to immunophenotype the immunologic response using specific antibodies to T-cell subsets (CD3, CD4, and CD8)...

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Immunopathogenesis of olmesartan-associated enteropathy.

BACKGROUND Olmesartan-associated enteropathy (OAE) is characterised by diarrhoea, nausea, vomiting, abdominal pain, weight loss and severe sprue-like enteropathy, all of which are resolved after discontinuation of olmesartan medoximil. AIM To determine the mechanistic similarities of OAE with coeliac sprue. METHODS Duodenal biopsies were extracted from OAE patients before (n = 11) or after ...

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Proliferative enteropathy: a global enteric disease of pigs caused by Lawsonia intracellularis.

Proliferative enteropathy (PE; ileitis) is a common intestinal disease affecting susceptible pigs raised under various management systems around the world. Major developments in the understanding of PE and its causative agent, Lawsonia intracellularis, have occurred that have led to advances in the detection of this disease and methods to control and prevent it. Diagnostic tools that have impro...

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In vitro testing of antimicrobial agents for proliferative enteropathy (ileitis)

Proliferative enteropathy (ileitis) is a common disease of grower and finisher pigs. Recent studies by the authors have illustrated reliable methods of in vitro culture of the etiologic agent, an obligate intracellular bacterium, known as ileal symbiont (IS) intracellularis.Characteristic lesions of proliferative enteropathy are reproduced when IS intracellularis is used as oral inocula in chal...

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Reduced use of antimicrobials after vaccination of pigs against porcine proliferative enteropathy in a Danish SPF herd

The present study explored whether the use of group medication with antibiotics in a Danish pig herd was reduced after vaccination of the pigs against proliferative enteropathy (PE) caused by Lawsonia intracellularis. 7900 pigs originating from a single commercial sow herd were vaccinated against L. intracellularis, whereas 7756 pigs were kept as non-vaccinated controls. The pigs were included ...

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ژورنال

عنوان ژورنال: Veterinary Pathology

سال: 2003

ISSN: 0300-9858,1544-2217

DOI: 10.1354/vp.40-4-421